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BIC at the Icahn School of Medicine at Mount Sinai


MAPPING NEURAL MECHANISMS
IN HEALTH AND DISEASE



The Brain Imaging Center (BIC) was launched in 2013 to lead and enhance brain imaging research in the new Leon and Norma Hess Center for Science and Medicine at Mount Sinai. BIC bridges the Friedman Brain Institute (FBI) and the Translational and Molecular Imaging Institute (TMII) to allow ground-breaking brain imaging research to be carried out collaboratively across departments.

The BIC’s aim is to support individual projects in gaining high-quality results while building a comprehensive data collection spanning brain disorders and developmental stages. The BIC has been standardizing acquisition and analyses of all brain imaging, spanning structural and functional (resting-state, task) scans, with the goal of imbuing these imaging results with in-depth characterizations of behavior, cognition, emotion and personality, supplemented by individuals’ genetic and metabolomics profiles.

The goal is to acquire data in a longitudinal, cross-pathology and cross-generational approach. That is, individuals can be scanned on a yearly basis to predict outcomes and developmental trajectories across brain disorders; their first degree relatives can also be scanned to identify predisposing and resilience factors.

At BIC, a cross-modality approach – using standardized protocols for 3T, 7T and PET/MR – with enhanced resolution and incorporating molecular/mechanistic explanations, offers unparalleled visualization for studies of the functioning brain. BIC's well-established and expertly-supported functional (task and resting state) protocols yield reliable, meaningful information about brain function.

Behavior and physiological measures including skin conductance, heart and respiration rates, pupil dilation and eye tracking can be studied while scanning.

BIC’s state-of-the-art functional techniques are complemented by structural (including diffusion) and molecular protocols that yield reliable, meaningful information about brain morphology, microstructure, connectivity and mechanisms.

BIC supports the development of imaging modalities to further enhance understanding of brain structure and function. Multi-band, multi-echo sequence development to refine and speed the processing of connectivity within the brain, magnetic resonance spectroscopy to examine neurotransmitter and other molecular changes, and arterial spin labeling to examine drug and medication modulation of brain function are all underway at BIC.

fMRI-compatible EEG-based measures such as cognitive event-related potentials, brain computer interfaces and neurofeedback are also under development at BIC. 

Investigators in the Mount Sinai health system and from collaborating research institutions have new access to cutting-edge imaging tools, methods and efficient automated analysis pipelines that facilitate the study of the brain as it engages in the complexity of living and copes with disease.

The BIC initiative is recruiting Investigators across a wide variety of medical research interests. For more information about facilities, programs, or about establishing your connection to BIC, please contact us.

Rita Z. Goldstein, Ph.D., is Professor of Psychiatry and Neuroscience, and BIC's Chief. Read More

Dr. Goldstein envisions the growing number of BIC-affiliated laboratories spanning multiple ISMMS departments, with shared interests crossing departmental (and institutional) lines.




















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